Assay Detail
Binding
CHEMBL5235433
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-spiperone from human D4 receptor assessed as inhibition constant
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent findings leading to the discovery of selective dopamine D<sub>4</sub> receptor ligands for the treatment of widespread diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.19 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL362542 | — | — | 1 | 8.57 |
| CHEMBL45244 | PD-168,077 | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL362542 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL45244 | PD-168,077 | Ki | = | 16.0 | nM | 7.80 |