Assay Detail

CHEMBL5235459

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

In vivo inhibition of BRD4 in human MV4-11 cells xenografted in mouse tumor model

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MV4-11
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Targeting MYC: From understanding its biology to drug discovery.

Ross J, Miron CE, Plescia J, Laplante P, McBride K, Moitessier N, Möröy T.
Eur J Med Chem (2021) 213 : 113137 -113137
PubMed 33460833 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.92	6.92

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4303404	PELABRESIB	3.0	1	6.92

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4303404	PELABRESIB	IC50	=	120.0	nM	6.92