Assay Detail
Binding
CHEMBL5235852
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human wild type DYRK1A (M1 to S629) expressed in bacterial system by Ambit Kinomescan binding assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (CHEMBL2292) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
DYRK1A Inhibitors as Potential Therapeutics for β-Cell Regeneration for Diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.61 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5186778 | — | — | 1 | 8.22 |
| CHEMBL4638292 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5186778 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4638292 | — | IC50 | = | 100.0 | nM | 7.00 |