Assay Detail
Binding
CHEMBL5236033
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Inhibition of human Cathepsin C using Ala-4-[ 125 I]Phe-DMK as substrate preincubated for 30 mins followed by substrate addition measured after 6 to 24 hrs
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cathepsin C inhibitors as anti-inflammatory drug discovery: Challenges and opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.15 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL450997 | — | — | 1 | 9.00 |
| CHEMBL448143 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL450997 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL448143 | — | IC50 | = | 50.0 | nM | 7.30 |