Assay Detail
Functional
CHEMBL5236315
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Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HGC-27 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and bioactivity evaluation of novel N-phenyl-substituted evodiamine derivatives as potent anti-tumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.44 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 6.66 |
| CHEMBL5073538 | — | — | 1 | 6.43 |
| CHEMBL5079574 | — | — | 1 | 6.35 |
| CHEMBL5094503 | — | — | 1 | 5.67 |
| CHEMBL5270585 | — | — | 1 | 5.61 |
| CHEMBL5089779 | — | — | 1 | 5.47 |
| CHEMBL5283736 | — | — | 1 | 5.44 |
| CHEMBL5089863 | — | — | 1 | 5.43 |
| CHEMBL5279850 | — | — | 1 | 5.39 |
| CHEMBL5277629 | — | — | 1 | 5.37 |
| CHEMBL5286877 | — | — | 1 | 5.33 |
| CHEMBL5088943 | — | — | 1 | 5.27 |
| CHEMBL5273886 | — | — | 1 | 5.16 |
| CHEMBL5291173 | — | — | 1 | 4.96 |
| CHEMBL5273905 | — | — | 1 | 4.90 |
| CHEMBL5270892 | — | — | 1 | 4.84 |
| CHEMBL5281324 | — | — | 1 | 4.83 |
| CHEMBL5085517 | — | — | 1 | 4.78 |
| CHEMBL5290442 | — | — | 1 | - |
| CHEMBL5289802 | — | — | 1 | - |
| CHEMBL5278401 | — | — | 1 | - |
| CHEMBL5090109 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84 | TOPOTECAN | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL5073538 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5079574 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5094503 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL5270585 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL5089779 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL5283736 | — | IC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL5089863 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL5279850 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5277629 | — | IC50 | = | 4240.0 | nM | 5.37 |
| CHEMBL5286877 | — | IC50 | = | 4660.0 | nM | 5.33 |
| CHEMBL5088943 | — | IC50 | = | 5330.0 | nM | 5.27 |
| CHEMBL5273886 | — | IC50 | = | 6980.0 | nM | 5.16 |
| CHEMBL5291173 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL5273905 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL5270892 | — | IC50 | = | 14380.0 | nM | 4.84 |
| CHEMBL5281324 | — | IC50 | = | 14950.0 | nM | 4.83 |
| CHEMBL5085517 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL5290442 | — | IC50 | > | 18000.0 | nM | - |
| CHEMBL5289802 | — | IC50 | > | 18000.0 | nM | - |
| CHEMBL5278401 | — | IC50 | > | 18000.0 | nM | - |
| CHEMBL5090109 | — | IC50 | > | 18000.0 | nM | - |