Assay Detail
Functional
CHEMBL5236368
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Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Indole derivatives as tubulin polymerization inhibitors for the development of promising anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.68 | 7.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5266843 | — | — | 1 | 7.99 |
| CHEMBL5269666 | — | — | 1 | 7.70 |
| CHEMBL5280461 | — | — | 1 | 6.96 |
| CHEMBL5279612 | — | — | 1 | 6.96 |
| CHEMBL5280217 | — | — | 1 | 6.89 |
| CHEMBL5279082 | — | — | 1 | 6.80 |
| CHEMBL4092940 | — | — | 1 | 5.25 |
| CHEMBL5274508 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5266843 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL5269666 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5280461 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5279612 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5280217 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5279082 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4092940 | — | IC50 | = | 5560.0 | nM | 5.25 |
| CHEMBL5274508 | — | IC50 | = | 14200.0 | nM | 4.85 |