Assay Detail
Binding
CHEMBL5236414
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human PCSK9
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proprotein convertase subtilisin/kexin type 9 (CHEMBL2929) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent Update on the Development of PCSK9 Inhibitors for Hypercholesterolemia Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 7.32 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5271747 | — | — | 1 | 9.52 |
| CHEMBL5280306 | — | — | 1 | 8.26 |
| CHEMBL5278292 | — | — | 1 | 8.21 |
| CHEMBL5273270 | — | — | 1 | 7.82 |
| CHEMBL5278470 | — | — | 1 | 6.41 |
| CHEMBL4226740 | — | — | 1 | 6.16 |
| CHEMBL4227325 | — | — | 1 | 6.16 |
| CHEMBL5279432 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5271747 | — | Kd | = | 0.3 | nM | 9.52 |
| CHEMBL5280306 | — | Kd | = | 5.5 | nM | 8.26 |
| CHEMBL5278292 | — | Kd | = | 6.1 | nM | 8.21 |
| CHEMBL5273270 | — | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL5278470 | — | Kd | = | 390.0 | nM | 6.41 |
| CHEMBL4226740 | — | Kd | = | 700.0 | nM | 6.16 |
| CHEMBL4227325 | — | Kd | = | 700.0 | nM | 6.16 |
| CHEMBL5279432 | — | Kd | = | 1000.0 | nM | 6.00 |