Assay Detail
Binding
CHEMBL5236429
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Inhibition of HMG CoA reductase (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL402) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent Update on the Development of PCSK9 Inhibitors for Hypercholesterolemia Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.05 | 4.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5278854 | — | — | 1 | 4.05 |
| CHEMBL5287357 | — | — | 1 | - |
| CHEMBL5277547 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5278854 | — | IC50 | = | 88900.0 | nM | 4.05 |
| CHEMBL5287357 | — | IC50 | = | 147200.0 | nM | - |
| CHEMBL5277547 | — | IC50 | = | 175300.0 | nM | - |