Assay Detail
Functional
CHEMBL5236727
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Anti-inflammatory activity against human PBMCs assessed as reduction in LPS-induced TNF-alpha release by ELISA analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Furazans in Medicinal Chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.46 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 8.46 |
| CHEMBL193240 | ROFLUMILAST | 4.0 | 1 | 7.30 |
| CHEMBL77826 | — | — | 1 | 7.17 |
| CHEMBL2172374 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511115 | CILOMILAST | EC50 | = | 3.47 | nM | 8.46 |
| CHEMBL193240 | ROFLUMILAST | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL77826 | — | EC50 | = | 67.6 | nM | 7.17 |
| CHEMBL2172374 | — | EC50 | = | 126.0 | nM | 6.90 |