Assay Detail
Binding
CHEMBL5236877
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TTBK1 in human HEK293T cells incubated for 1 hrs by HTRF assay
24
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.23 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5283456 | — | — | 1 | 7.38 |
| CHEMBL5268795 | — | — | 1 | 7.01 |
| CHEMBL5282072 | — | — | 1 | 6.94 |
| CHEMBL5279863 | — | — | 1 | 6.79 |
| CHEMBL5272364 | — | — | 1 | 6.75 |
| CHEMBL5282902 | — | — | 1 | 6.65 |
| CHEMBL5268080 | — | — | 1 | 6.62 |
| CHEMBL5273263 | — | — | 1 | 6.59 |
| CHEMBL5280210 | — | — | 1 | 6.50 |
| CHEMBL5275588 | — | — | 1 | 6.42 |
| CHEMBL5278744 | — | — | 1 | 6.24 |
| CHEMBL5290581 | — | — | 1 | 6.24 |
| CHEMBL5288487 | — | — | 1 | 6.13 |
| CHEMBL5271137 | — | — | 1 | 6.13 |
| CHEMBL5290252 | — | — | 2 | 5.85 |
| CHEMBL5274162 | — | — | 1 | 5.78 |
| CHEMBL5274528 | — | — | 1 | 5.73 |
| CHEMBL2334586 | — | — | 1 | 5.73 |
| CHEMBL5280803 | — | — | 1 | 5.60 |
| CHEMBL5279159 | — | — | 1 | 5.45 |
| CHEMBL5272862 | — | — | 1 | 5.07 |
| CHEMBL5282564 | — | — | 1 | - |
| CHEMBL5181163 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5283456 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5268795 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL5282072 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL5279863 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL5272364 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL5282902 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL5268080 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL5273263 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL5280210 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL5275588 | — | IC50 | = | 377.0 | nM | 6.42 |
| CHEMBL5290581 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL5278744 | — | IC50 | = | 571.0 | nM | 6.24 |
| CHEMBL5271137 | — | IC50 | = | 737.0 | nM | 6.13 |
| CHEMBL5288487 | — | IC50 | = | 742.0 | nM | 6.13 |
| CHEMBL5290252 | — | IC50 | = | 1415.0 | nM | 5.85 |
| CHEMBL5274162 | — | IC50 | = | 1646.0 | nM | 5.78 |
| CHEMBL5274528 | — | IC50 | = | 1852.0 | nM | 5.73 |
| CHEMBL2334586 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL5280803 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5279159 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL5290252 | — | IC50 | = | 3603.0 | nM | 5.44 |
| CHEMBL5272862 | — | IC50 | = | 8482.0 | nM | 5.07 |
| CHEMBL5282564 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5181163 | — | IC50 | > | 10000.0 | nM | - |