Assay Detail

CHEMBL5237000

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Functional

Cytotoxicity against human SMMC-7721 cells by SRB assay

ChEMBL ↗

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Target

SMMC-7721 (CHEMBL613831) ↗

Open DB target context

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SMMC-7721 (CHEMBL613831) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target SMMC-7721

CHEMBL613831

Anchored from Assay target.

Protein identity SMMC-7721

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	SMMC-7721
Confidence	1 — Organism
Curated By	Autocuration

Target

SMMC-7721 (CHEMBL613831) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Marine Natural Products: A Potential Source of Anti-hepatocellular Carcinoma Drugs.

Ren X, Xie X, Chen B, Liu L, Jiang C, Qian Q.
J Med Chem (2021) 64 : 7879 -7899
PubMed 34128674 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.82	7.48

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5284106	—	—	1	7.48
CHEMBL53463	DOXORUBICIN	4.0	1	6.15

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5284106	—	IC50	=	33.0	nM	7.48
CHEMBL53463	DOXORUBICIN	IC50	=	706.0	nM	6.15