Assay Detail
Binding
CHEMBL5237418
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Inhibition of N-terminal his6-tagged human KDM5A (1 to 797 residues) expressed in sf9 insect cells incubated for 20 mins by Alphascreen assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pharmacological inhibition of KDM5A for cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.78 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3787669 | — | — | 1 | 7.60 |
| CHEMBL5268189 | — | — | 1 | 7.00 |
| CHEMBL5290530 | — | — | 1 | 5.96 |
| CHEMBL316034 | — | — | 1 | 5.31 |
| CHEMBL3786952 | — | — | 1 | 5.30 |
| CHEMBL5277662 | — | — | 1 | 5.22 |
| CHEMBL5278205 | — | — | 1 | 5.16 |
| CHEMBL2169917 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3787669 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5268189 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5290530 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL316034 | — | IC50 | = | 4920.0 | nM | 5.31 |
| CHEMBL3786952 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5277662 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5278205 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2169917 | — | IC50 | = | 20000.0 | nM | 4.70 |