Assay Detail
Binding
CHEMBL5237934
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to VHL E3 ligase (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
von Hippel-Lindau disease tumor suppressor (CHEMBL3108660) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Drug Hunting at the Nexus of Medicinal Chemistry and Chemical Biology and the Discovery of Novel Therapeutic Modalities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 5.30 | 6.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3344081 | — | — | 1 | 6.73 |
| CHEMBL3344079 | — | — | 1 | 5.49 |
| CHEMBL3108881 | — | — | 1 | 5.27 |
| CHEMBL3343404 | — | — | 1 | 4.65 |
| CHEMBL5266076 | — | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3344081 | — | Kd | = | 185.0 | nM | 6.73 |
| CHEMBL3344079 | — | Kd | = | 3270.0 | nM | 5.49 |
| CHEMBL3108881 | — | Kd | = | 5400.0 | nM | 5.27 |
| CHEMBL3343404 | — | Kd | = | 22200.0 | nM | 4.65 |
| CHEMBL5266076 | — | Kd | = | 45500.0 | nM | 4.34 |