Assay Detail
Binding
CHEMBL5237955
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human ADAMTS-4
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
A disintegrin and metalloproteinase with thrombospondin motifs 4 (CHEMBL2318) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting Aggrecanases for Osteoarthritis Therapy: From Zinc Chelation to Exosite Inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.85 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24398 | — | — | 1 | 8.52 |
| CHEMBL8943 | — | — | 1 | 7.19 |
| CHEMBL1766896 | — | — | 1 | 6.68 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24398 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL8943 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1766896 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 9800.0 | nM | 5.01 |