Assay Detail
Binding
CHEMBL5237969
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ADAMTS-4 (unknown origin)
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
A disintegrin and metalloproteinase with thrombospondin motifs 4 (CHEMBL2318) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting Aggrecanases for Osteoarthritis Therapy: From Zinc Chelation to Exosite Inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.00 | 7.00 |
| Ki | 2 | 5.39 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 7.00 |
| CHEMBL36327 | EPICATECHIN GALLATE | — | 1 | 7.00 |
| CHEMBL69863 | PICEATANNOL | — | 1 | 5.57 |
| CHEMBL307145 | PYROGALLOL | -1.0 | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL36327 | EPICATECHIN GALLATE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL69863 | PICEATANNOL | Ki | = | 2680.0 | nM | 5.57 |
| CHEMBL307145 | PYROGALLOL | Ki | = | 6340.0 | nM | 5.20 |