Assay Detail
Toxicity
CHEMBL5238147
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of oxazoline enhancers of cellular progranulin release.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.50 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1734 | SOLIFENACIN | 4.0 | 1 | 6.57 |
| CHEMBL5284728 | — | — | 1 | 6.47 |
| CHEMBL5270350 | — | — | 1 | 6.29 |
| CHEMBL5278585 | — | — | 1 | 6.17 |
| CHEMBL5290639 | — | — | 1 | 6.16 |
| CHEMBL5267232 | — | — | 1 | 5.77 |
| CHEMBL5288288 | — | — | 1 | 5.66 |
| CHEMBL5273870 | — | — | 1 | 5.64 |
| CHEMBL5287100 | — | — | 1 | 5.51 |
| CHEMBL5268245 | — | — | 1 | 5.51 |
| CHEMBL5288534 | — | — | 1 | 5.48 |
| CHEMBL5285699 | — | — | 1 | 5.44 |
| CHEMBL5280684 | — | — | 1 | 5.44 |
| CHEMBL5287033 | — | — | 1 | 5.41 |
| CHEMBL5271222 | — | — | 1 | 5.36 |
| CHEMBL5267767 | — | — | 1 | 5.32 |
| CHEMBL5269880 | — | — | 1 | 5.32 |
| CHEMBL5279044 | — | — | 1 | 5.29 |
| CHEMBL5288607 | — | — | 1 | 5.27 |
| CHEMBL5281792 | — | — | 1 | 5.21 |
| CHEMBL5275548 | — | — | 1 | 5.17 |
| CHEMBL5289822 | — | — | 1 | 5.16 |
| CHEMBL5281603 | — | — | 1 | 5.11 |
| CHEMBL5272819 | — | — | 1 | 5.06 |
| CHEMBL5284190 | — | — | 1 | 5.00 |
| CHEMBL5268324 | — | — | 1 | 4.96 |
| CHEMBL5289562 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1734 | SOLIFENACIN | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5284728 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5270350 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5278585 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL5290639 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL5267232 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5288288 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5273870 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5287100 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5268245 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5288534 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL5285699 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5280684 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5287033 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5271222 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5267767 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5269880 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5279044 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL5288607 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5281792 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5275548 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL5289822 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5281603 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5272819 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL5284190 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5268324 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5289562 | — | IC50 | = | 21000.0 | nM | 4.68 |