Assay Detail
Binding
CHEMBL5238333
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human wild type RET
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase receptor Ret (CHEMBL2041) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting Gatekeeper Mutations for Kinase Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 9.40 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4582651 | PRALSETINIB | 4.0 | 1 | 9.40 |
| CHEMBL4559134 | SELPERCATINIB | 4.0 | 1 | 9.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4582651 | PRALSETINIB | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4559134 | SELPERCATINIB | IC50 | = | 0.4 | nM | 9.40 |