Assay Detail
Binding
CHEMBL5238861
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse EGFR L858R mutant stably expressed in mouse BaF3 cells assessed as cell viability incubated for 3 days by Cell Titer-Glo assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.48 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4650319 | MOBOCERTINIB | 4.0 | 1 | 8.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4650319 | MOBOCERTINIB | IC50 | = | 3.3 | nM | 8.48 |