Assay Detail
Functional
CHEMBL5239508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel <i>N</i>-Heterocyclic-Fused Deoxypodophyllotoxin Analogues as Tubulin Polymerization Inhibitors Targeting the Colchicine-Binding Site for Cancer Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 7.32 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5285469 | — | — | 1 | 8.46 |
| CHEMBL5278215 | — | — | 1 | 8.37 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.23 |
| CHEMBL5290952 | — | — | 1 | 8.23 |
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | — | 1 | 8.22 |
| CHEMBL5270408 | — | — | 1 | 8.04 |
| CHEMBL5267653 | — | — | 1 | 7.94 |
| CHEMBL5279482 | — | — | 1 | 7.77 |
| CHEMBL5280517 | — | — | 1 | 7.76 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.71 |
| CHEMBL5267862 | — | — | 1 | 7.66 |
| CHEMBL5266246 | — | — | 1 | 7.47 |
| CHEMBL5280318 | — | — | 1 | 7.45 |
| CHEMBL5270097 | — | — | 1 | 7.44 |
| CHEMBL5266589 | — | — | 1 | 7.43 |
| CHEMBL5271208 | — | — | 1 | 7.39 |
| CHEMBL5288932 | — | — | 1 | 7.31 |
| CHEMBL5285093 | — | — | 1 | 7.23 |
| CHEMBL5271475 | — | — | 1 | 7.00 |
| CHEMBL5268748 | — | — | 1 | 6.90 |
| CHEMBL5275247 | — | — | 1 | 6.83 |
| CHEMBL5272848 | — | — | 1 | 6.58 |
| CHEMBL5287107 | — | — | 1 | 6.42 |
| CHEMBL5277560 | — | — | 1 | 6.40 |
| CHEMBL5267940 | — | — | 1 | 6.01 |
| CHEMBL5284983 | — | — | 1 | 5.81 |
| CHEMBL5281262 | — | — | 1 | 5.63 |
| CHEMBL5269006 | — | — | 1 | - |
| CHEMBL5289356 | — | — | 1 | - |
| CHEMBL5279063 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5285469 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL5278215 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL5290952 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5270408 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL5267653 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL5279482 | — | IC50 | = | 16.9 | nM | 7.77 |
| CHEMBL5280517 | — | IC50 | = | 17.32 | nM | 7.76 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL5267862 | — | IC50 | = | 21.9 | nM | 7.66 |
| CHEMBL5266246 | — | IC50 | = | 33.6 | nM | 7.47 |
| CHEMBL5280318 | — | IC50 | = | 35.4 | nM | 7.45 |
| CHEMBL5270097 | — | IC50 | = | 36.2 | nM | 7.44 |
| CHEMBL5266589 | — | IC50 | = | 37.5 | nM | 7.43 |
| CHEMBL5271208 | — | IC50 | = | 40.7 | nM | 7.39 |
| CHEMBL5288932 | — | IC50 | = | 48.81 | nM | 7.31 |
| CHEMBL5285093 | — | IC50 | = | 58.8 | nM | 7.23 |
| CHEMBL5271475 | — | IC50 | = | 100.1 | nM | 7.00 |
| CHEMBL5268748 | — | IC50 | = | 125.3 | nM | 6.90 |
| CHEMBL5275247 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL5272848 | — | IC50 | = | 265.1 | nM | 6.58 |
| CHEMBL5287107 | — | IC50 | = | 375.8 | nM | 6.42 |
| CHEMBL5277560 | — | IC50 | = | 399.5 | nM | 6.40 |
| CHEMBL5267940 | — | IC50 | = | 965.1 | nM | 6.01 |
| CHEMBL5284983 | — | IC50 | = | 1559.0 | nM | 5.81 |
| CHEMBL5281262 | — | IC50 | = | 2332.0 | nM | 5.63 |
| CHEMBL5279669 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5277679 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5279715 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5274592 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5282905 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5276378 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5286822 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5280459 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5273347 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5268624 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5276684 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5279063 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5289356 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5269006 | — | IC50 | > | 5000.0 | nM | - |