Assay Detail
Functional
CHEMBL5239509
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTT assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel <i>N</i>-Heterocyclic-Fused Deoxypodophyllotoxin Analogues as Tubulin Polymerization Inhibitors Targeting the Colchicine-Binding Site for Cancer Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 7.28 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5278215 | — | — | 1 | 8.62 |
| CHEMBL5285469 | — | — | 1 | 8.36 |
| CHEMBL5290952 | — | — | 1 | 8.22 |
| CHEMBL5270408 | — | — | 1 | 8.08 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.97 |
| CHEMBL5280517 | — | — | 1 | 7.83 |
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | — | 1 | 7.78 |
| CHEMBL5267653 | — | — | 1 | 7.74 |
| CHEMBL5279482 | — | — | 1 | 7.67 |
| CHEMBL5288932 | — | — | 1 | 7.63 |
| CHEMBL5267862 | — | — | 1 | 7.58 |
| CHEMBL5266246 | — | — | 1 | 7.57 |
| CHEMBL5280318 | — | — | 1 | 7.35 |
| CHEMBL5266589 | — | — | 1 | 7.32 |
| CHEMBL5268748 | — | — | 1 | 7.31 |
| CHEMBL5271208 | — | — | 1 | 7.30 |
| CHEMBL5271475 | — | — | 1 | 7.25 |
| CHEMBL5287107 | — | — | 1 | 7.20 |
| CHEMBL5270097 | — | — | 1 | 7.13 |
| CHEMBL5272848 | — | — | 1 | 7.13 |
| CHEMBL5285093 | — | — | 1 | 7.09 |
| CHEMBL5275247 | — | — | 1 | 6.67 |
| CHEMBL5277560 | — | — | 1 | 6.45 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.41 |
| CHEMBL5267940 | — | — | 1 | 6.21 |
| CHEMBL5284983 | — | — | 1 | 6.13 |
| CHEMBL5276378 | — | — | 1 | 6.12 |
| CHEMBL5281262 | — | — | 1 | 5.72 |
| CHEMBL5273347 | — | — | 1 | - |
| CHEMBL5279669 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5278215 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5285469 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL5290952 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5270408 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL5280517 | — | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL5267653 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL5279482 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL5288932 | — | IC50 | = | 23.2 | nM | 7.63 |
| CHEMBL5267862 | — | IC50 | = | 26.3 | nM | 7.58 |
| CHEMBL5266246 | — | IC50 | = | 26.7 | nM | 7.57 |
| CHEMBL5280318 | — | IC50 | = | 44.3 | nM | 7.35 |
| CHEMBL5266589 | — | IC50 | = | 48.4 | nM | 7.32 |
| CHEMBL5268748 | — | IC50 | = | 49.1 | nM | 7.31 |
| CHEMBL5271208 | — | IC50 | = | 49.9 | nM | 7.30 |
| CHEMBL5271475 | — | IC50 | = | 56.8 | nM | 7.25 |
| CHEMBL5287107 | — | IC50 | = | 63.4 | nM | 7.20 |
| CHEMBL5270097 | — | IC50 | = | 74.8 | nM | 7.13 |
| CHEMBL5272848 | — | IC50 | = | 74.8 | nM | 7.13 |
| CHEMBL5285093 | — | IC50 | = | 81.9 | nM | 7.09 |
| CHEMBL5275247 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL5277560 | — | IC50 | = | 356.8 | nM | 6.45 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 390.8 | nM | 6.41 |
| CHEMBL5267940 | — | IC50 | = | 610.9 | nM | 6.21 |
| CHEMBL5284983 | — | IC50 | = | 749.0 | nM | 6.13 |
| CHEMBL5276378 | — | IC50 | = | 754.8 | nM | 6.12 |
| CHEMBL5281262 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL5280459 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5279063 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5269006 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5289356 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5276684 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5286822 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5277679 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5268624 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5282905 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5274592 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5279715 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5279669 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5273347 | — | IC50 | > | 5000.0 | nM | - |