Assay Detail
Functional
CHEMBL5239548
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Antiproliferative activity against paclitaxel-resistant human MCF7/TxR cells measured after 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7/TxR |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Novel <i>N</i>-Heterocyclic-Fused Deoxypodophyllotoxin Analogues as Tubulin Polymerization Inhibitors Targeting the Colchicine-Binding Site for Cancer Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.44 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5285469 | — | — | 1 | 8.28 |
| CHEMBL5270408 | — | — | 1 | 8.11 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.81 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5285469 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL5270408 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 15.4 | nM | 7.81 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2750.0 | nM | 5.56 |