Assay Detail
Binding
CHEMBL5239614
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Inhibition of GST-tagged bacterial beta-lactamase NMD-1 expressed in Escherichia coli BL21(DE3) using CCF2-FA as substrate by fluorescence assay
22
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.47 | 9.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5290687 | — | — | 1 | 9.61 |
| CHEMBL5266666 | — | — | 1 | 8.62 |
| CHEMBL5284114 | — | — | 1 | 8.52 |
| CHEMBL5279817 | — | — | 1 | 8.48 |
| CHEMBL61916 | — | — | 1 | 8.46 |
| CHEMBL5284444 | — | — | 2 | 8.43 |
| CHEMBL5278580 | — | — | 1 | 7.68 |
| CHEMBL5268582 | — | — | 1 | 7.62 |
| CHEMBL5267155 | — | — | 1 | 7.46 |
| CHEMBL5279683 | — | — | 1 | 7.46 |
| CHEMBL5287735 | — | — | 1 | 7.46 |
| CHEMBL5271066 | — | — | 1 | 7.44 |
| CHEMBL5274841 | — | — | 1 | 7.44 |
| CHEMBL5277681 | — | — | 1 | 7.39 |
| CHEMBL4745006 | — | — | 1 | 7.36 |
| CHEMBL26514 | — | — | 1 | 7.28 |
| CHEMBL5285307 | — | — | 1 | 6.15 |
| CHEMBL5281100 | — | — | 1 | 5.50 |
| CHEMBL5291449 | — | — | 1 | 5.30 |
| CHEMBL5285776 | — | — | 1 | 4.80 |
| CHEMBL5268806 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5290687 | — | IC50 | = | 0.243 | nM | 9.61 |
| CHEMBL5266666 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5284114 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5279817 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL61916 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL5284444 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5284444 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL5278580 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5268582 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5267155 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5279683 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5287735 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5271066 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5274841 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5277681 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4745006 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL26514 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5285307 | — | IC50 | = | 704.0 | nM | 6.15 |
| CHEMBL5281100 | — | IC50 | = | 3167.0 | nM | 5.50 |
| CHEMBL5291449 | — | IC50 | = | 4965.0 | nM | 5.30 |
| CHEMBL5285776 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL5268806 | — | IC50 | > | 200.0 | nM | - |