Assay Detail
Functional
CHEMBL5239933
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Antiplasmodial activity against early stage (I to III) Plasmodium falciparum incubated for 48 hrs by bioluminescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and <i>In Vivo</i> Efficacy in a <i>Plasmodium berghei</i> Mouse Malaria Infection Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.06 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | 4.0 | 1 | 6.70 |
| CHEMBL5286751 | — | — | 1 | 5.93 |
| CHEMBL5273140 | — | — | 1 | 5.82 |
| CHEMBL5267563 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5286751 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL5273140 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL5267563 | — | IC50 | = | 1670.0 | nM | 5.78 |