Assay Detail
Functional
CHEMBL5240446
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Antiproliferative activity against human UM-UC-9 assessed as inhibition of cell proliferation measured after 7 days by IncuCyte live-cell imaging assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | UM-UC-9 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.85 | 7.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5281842 | — | — | 1 | 7.73 |
| CHEMBL5267263 | — | — | 1 | 7.71 |
| CHEMBL5282503 | — | — | 1 | 7.51 |
| CHEMBL5286386 | — | — | 1 | 7.39 |
| CHEMBL5272194 | — | — | 1 | 7.20 |
| CHEMBL5273393 | — | — | 1 | 7.19 |
| CHEMBL5271038 | — | — | 1 | 7.01 |
| CHEMBL5285688 | — | — | 1 | 6.78 |
| CHEMBL5277957 | — | — | 1 | 6.16 |
| CHEMBL5273751 | — | — | 1 | 5.33 |
| CHEMBL5291018 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5281842 | — | IC50 | = | 18.7 | nM | 7.73 |
| CHEMBL5267263 | — | IC50 | = | 19.4 | nM | 7.71 |
| CHEMBL5282503 | — | IC50 | = | 30.9 | nM | 7.51 |
| CHEMBL5286386 | — | IC50 | = | 40.4 | nM | 7.39 |
| CHEMBL5272194 | — | IC50 | = | 62.7 | nM | 7.20 |
| CHEMBL5273393 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5271038 | — | IC50 | = | 98.3 | nM | 7.01 |
| CHEMBL5285688 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL5277957 | — | IC50 | = | 695.0 | nM | 6.16 |
| CHEMBL5273751 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL5291018 | — | IC50 | = | 4830.0 | nM | 5.32 |