Assay Detail
Functional
CHEMBL5240519
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MM4-11 cells assessed as inhibition of cell growth incubated for 72 hrs MTS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of BRD4 degraders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.69 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5276454 | — | — | 1 | 8.52 |
| CHEMBL5285715 | — | — | 1 | 8.10 |
| CHEMBL5290363 | — | — | 1 | 8.00 |
| CHEMBL4094346 | — | — | 1 | 7.89 |
| CHEMBL5283271 | — | — | 1 | 7.75 |
| CHEMBL5277943 | — | — | 1 | 7.75 |
| CHEMBL5268063 | — | — | 1 | 7.60 |
| CHEMBL5277333 | — | — | 1 | 7.58 |
| CHEMBL5284006 | — | — | 1 | 7.55 |
| CHEMBL1957266 | — | — | 1 | 7.38 |
| CHEMBL5271388 | — | — | 1 | 7.32 |
| CHEMBL5267648 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5276454 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5285715 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5290363 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4094346 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5283271 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5277943 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5268063 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5277333 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5284006 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1957266 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5271388 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5267648 | — | IC50 | = | 128.0 | nM | 6.89 |