Assay Detail
Functional
CHEMBL5240780
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of quinoxalinone derivatives as potent BRD4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.08 | 8.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5290384 | — | — | 1 | 8.71 |
| CHEMBL5285927 | — | — | 1 | 8.42 |
| CHEMBL5272457 | — | — | 1 | 8.33 |
| CHEMBL5269731 | — | — | 1 | 8.13 |
| CHEMBL5289077 | — | — | 1 | 8.01 |
| CHEMBL3987016 | MIVEBRESIB | 2.0 | 1 | 7.91 |
| CHEMBL5266305 | — | — | 1 | 7.66 |
| CHEMBL5290271 | — | — | 1 | 7.46 |
| CHEMBL5283605 | — | — | 1 | - |
| CHEMBL5280436 | — | — | 1 | - |
| CHEMBL5286474 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5290384 | — | IC50 | = | 1.93 | nM | 8.71 |
| CHEMBL5285927 | — | IC50 | = | 3.81 | nM | 8.42 |
| CHEMBL5272457 | — | IC50 | = | 4.64 | nM | 8.33 |
| CHEMBL5269731 | — | IC50 | = | 7.44 | nM | 8.13 |
| CHEMBL5289077 | — | IC50 | = | 9.78 | nM | 8.01 |
| CHEMBL3987016 | MIVEBRESIB | IC50 | = | 12.27 | nM | 7.91 |
| CHEMBL5266305 | — | IC50 | = | 22.06 | nM | 7.66 |
| CHEMBL5290271 | — | IC50 | = | 34.49 | nM | 7.46 |
| CHEMBL5283605 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL5280436 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL5286474 | — | IC50 | > | 50.0 | nM | - |