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Assay Detail

CHEMBL5241789

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Agonist activity at PPARgamma (unknown origin)
7
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Peroxisome proliferator-activated receptor gamma (CHEMBL235)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Natural products and analogs as preventive agents for metabolic syndrome via peroxisome proliferator-activated receptors: An overview.
Villarroel-Vicente C, Gutiérrez-Palomo S, Ferri J, Cortes D, Cabedo N.
Eur J Med Chem (2021) 221 : 113535 -113535
PubMed 33992930 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 4 5.45 6.33
EC50 3 6.42 7.14

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5268158 1 7.14
CHEMBL180920 MAGNOLOL 2 6.34
CHEMBL465718 DELTA9-TETRAHYDROCANNABINOLIC ACID A 1 6.33
CHEMBL13045 CHELERYTHRINE 1 6.25
CHEMBL150 KAEMPFEROL 1.0 1 4.64
CHEMBL50 QUERCETIN 3.0 1 4.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5268158 EC50 = 73.0 nM 7.14
CHEMBL180920 MAGNOLOL EC50 = 458.0 nM 6.34
CHEMBL465718 DELTA9-TETRAHYDROCANNABINOLIC ACID A IC50 = 470.0 nM 6.33
CHEMBL13045 CHELERYTHRINE IC50 = 566.0 nM 6.25
CHEMBL180920 MAGNOLOL EC50 = 1620.0 nM 5.79
CHEMBL150 KAEMPFEROL IC50 = 23100.0 nM 4.64
CHEMBL50 QUERCETIN IC50 = 26000.0 nM 4.58