Assay Detail
Binding
CHEMBL5242505
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Akt3 (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-gamma serine/threonine-protein kinase (CHEMBL4816) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Developments of CRBN-based PROTACs as potential therapeutic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.28 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5288938 | — | — | 1 | 8.46 |
| CHEMBL2177390 | IPATASERTIB | 3.0 | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5288938 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL2177390 | IPATASERTIB | IC50 | = | 8.0 | nM | 8.10 |