Assay Detail
Binding
CHEMBL5242612
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human 5-LOX using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthetically-tailored and nature-derived dual COX-2/5-LOX inhibitors: Structural aspects and SAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.87 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69863 | PICEATANNOL | — | 1 | 6.41 |
| CHEMBL83527 | PTEROSTILBENE | 2.0 | 1 | 5.79 |
| CHEMBL498917 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69863 | PICEATANNOL | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL83527 | PTEROSTILBENE | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL498917 | — | IC50 | = | 4010.0 | nM | 5.40 |