Assay Detail
Functional
CHEMBL5243052
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Antiproliferative activity against human NCI-H460 cells harboring wild type p53 assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.67 | 4.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5290005 | — | — | 1 | 4.67 |
| CHEMBL4802045 | BAY-091 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5290005 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL4802045 | BAY-091 | IC50 | > | 30000.0 | nM | - |