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Assay Detail

CHEMBL5243073

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of 5-LOX (unknown origin) using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by absorbance based analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Non-steroidal anti-inflammatory drugs: recent advances in the use of synthetic COX-2 inhibitors.
Ahmadi M, Bekeschus S, Weltmann KD, von Woedtke T, Wende K.
RSC Med Chem (2022) 13 : 471 -496
PubMed 35685617 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 6.42 6.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5282397 1 6.42
CHEMBL5275204 1 6.42
CHEMBL5272126 1 6.42
CHEMBL5268121 1 6.42
CHEMBL5285788 1 6.42
CHEMBL5279078 1 6.42
CHEMBL5270094 1 6.42
CHEMBL5281704 1 6.42
CHEMBL5283995 1 6.42
CHEMBL5271136 1 6.42
CHEMBL5271871 1 6.42
CHEMBL5282918 1 6.42
CHEMBL5276822 1 6.42
CHEMBL5272361 1 6.42
CHEMBL5287114 1 6.42
CHEMBL5282180 1 6.42
CHEMBL5272671 1 6.42
CHEMBL5267656 1 6.42
CHEMBL5279175 1 6.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5282397 IC50 = 380.0 nM 6.42
CHEMBL5275204 IC50 = 380.0 nM 6.42
CHEMBL5272126 IC50 = 380.0 nM 6.42
CHEMBL5268121 IC50 = 380.0 nM 6.42
CHEMBL5285788 IC50 = 380.0 nM 6.42
CHEMBL5279078 IC50 = 380.0 nM 6.42
CHEMBL5270094 IC50 = 380.0 nM 6.42
CHEMBL5281704 IC50 = 380.0 nM 6.42
CHEMBL5283995 IC50 = 380.0 nM 6.42
CHEMBL5271136 IC50 = 380.0 nM 6.42
CHEMBL5271871 IC50 = 380.0 nM 6.42
CHEMBL5282918 IC50 = 380.0 nM 6.42
CHEMBL5276822 IC50 = 380.0 nM 6.42
CHEMBL5272361 IC50 = 380.0 nM 6.42
CHEMBL5287114 IC50 = 380.0 nM 6.42
CHEMBL5282180 IC50 = 380.0 nM 6.42
CHEMBL5272671 IC50 = 380.0 nM 6.42
CHEMBL5267656 IC50 = 380.0 nM 6.42
CHEMBL5279175 IC50 = 380.0 nM 6.42