Assay Detail
Binding
CHEMBL5243089
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Inhibition of DHFR (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Non-steroidal anti-inflammatory drugs: recent advances in the use of synthetic COX-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.64 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439 | SULFADIAZINE | 4.0 | 1 | 6.89 |
| CHEMBL5271705 | — | — | 1 | 6.55 |
| CHEMBL5276096 | — | — | 1 | 6.55 |
| CHEMBL5286217 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439 | SULFADIAZINE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5271705 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5276096 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5286217 | — | IC50 | = | 280.0 | nM | 6.55 |