Assay Detail
Binding
CHEMBL5243293
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human HCA2 expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Flp-In-293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Insights into the recent progress in the medicinal chemistry of pyranopyrimidine analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.29 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5270112 | — | — | 1 | 7.29 |
| CHEMBL5275861 | — | — | 1 | 7.29 |
| CHEMBL5284951 | — | — | 1 | 7.29 |
| CHEMBL5281556 | — | — | 1 | 7.29 |
| CHEMBL1672755 | — | — | 1 | 7.29 |
| CHEMBL5277000 | — | — | 1 | 7.29 |
| CHEMBL2036813 | — | — | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5270112 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5275861 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5284951 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5281556 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1672755 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5277000 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL2036813 | — | EC50 | = | 51.0 | nM | 7.29 |