Assay Detail

CHEMBL5243298

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Anticancer activity against human HepG2 cells assessed as cell growth inhibition incubated for 24 hrs

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

HepG2 (CHEMBL395) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

HepG2 (CHEMBL395) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target HepG2

CHEMBL395

Anchored from Assay target.

Protein identity HepG2

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HepG2
Confidence	1 — Organism
Curated By	Autocuration

Target

HepG2 (CHEMBL395) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Insights into the recent progress in the medicinal chemistry of pyranopyrimidine analogs.

Elattar KM, El-Khateeb AY, Hamed SE.
RSC Med Chem (2022) 13 : 522 -567
PubMed 35694689 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	6.26	6.58

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5267417	—	—	1	6.58
CHEMBL5268029	—	—	1	6.28
CHEMBL17289	CHS-828	1.0	1	5.91

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5267417	—	IC50	=	263.0	nM	6.58
CHEMBL5268029	—	IC50	=	523.0	nM	6.28
CHEMBL17289	CHS-828	IC50	=	1245.0	nM	5.91