Assay Detail
Binding
CHEMBL5243352
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of porcine pancreatic alpha-amylase preincubated for 10 mins followed by substrate starch addition and measured after 10 mins by colorimetric analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Insights into the recent progress in the medicinal chemistry of pyranopyrimidine analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.91 | 6.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404271 | ACARBOSE | 4.0 | 1 | 6.67 |
| CHEMBL5270068 | — | — | 1 | 5.19 |
| CHEMBL5266328 | — | — | 1 | 5.00 |
| CHEMBL5285447 | — | — | 1 | 4.85 |
| CHEMBL5279919 | — | — | 1 | 4.79 |
| CHEMBL5272008 | — | — | 1 | 4.70 |
| CHEMBL5271257 | — | — | 1 | 4.66 |
| CHEMBL5266358 | — | — | 1 | 4.65 |
| CHEMBL5290916 | — | — | 1 | 4.61 |
| CHEMBL5272468 | — | — | 1 | 4.57 |
| CHEMBL5278862 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404271 | ACARBOSE | IC50 | = | 213.7 | nM | 6.67 |
| CHEMBL5270068 | — | IC50 | = | 6490.0 | nM | 5.19 |
| CHEMBL5266328 | — | IC50 | = | 9897.0 | nM | 5.00 |
| CHEMBL5285447 | — | IC50 | = | 14112.0 | nM | 4.85 |
| CHEMBL5279919 | — | IC50 | = | 16107.0 | nM | 4.79 |
| CHEMBL5272008 | — | IC50 | = | 20131.0 | nM | 4.70 |
| CHEMBL5271257 | — | IC50 | = | 22068.0 | nM | 4.66 |
| CHEMBL5266358 | — | IC50 | = | 22604.0 | nM | 4.65 |
| CHEMBL5290916 | — | IC50 | = | 24723.0 | nM | 4.61 |
| CHEMBL5272468 | — | IC50 | = | 27087.0 | nM | 4.57 |
| CHEMBL5278862 | — | IC50 | = | 42797.0 | nM | 4.37 |