Assay Detail
Binding
CHEMBL5243510
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Src kinase (unknown origin) phosphorylation at Tyr416/419 residues incubated for 24 hrs by Western blot analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-Aminopyrazolopyrimidine scaffold and its deformation in the design of tyrosine and serine/threonine kinase inhibitors in medicinal chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.14 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5268244 | — | — | 1 | 8.64 |
| CHEMBL5280361 | — | — | 1 | 8.17 |
| CHEMBL45177 | — | — | 1 | 8.05 |
| CHEMBL475584 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5268244 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5280361 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL45177 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL475584 | — | IC50 | = | 20.0 | nM | 7.70 |