Assay Detail
Binding
CHEMBL5243686
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Inhibition of SOAT (unknown origin) in macrophage
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Macrophage |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Targeting Sterol <i>O</i>-Acyltransferase/Acyl-CoA:Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.59 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274185 | LECIMIBIDE | 2.0 | 1 | 7.60 |
| CHEMBL273826 | — | — | 1 | 7.60 |
| CHEMBL513892 | — | — | 1 | 7.05 |
| CHEMBL447977 | PACTIMIBE SULFATE | 2.0 | 1 | 5.72 |
| CHEMBL135534 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274185 | LECIMIBIDE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL273826 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL513892 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL447977 | PACTIMIBE SULFATE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL135534 | — | IC50 | = | 11000.0 | nM | 4.96 |