Assay Detail
Binding
CHEMBL5243702
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Inhibition of human SOAT2 expressed in mouse AC29 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | AC29 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting Sterol <i>O</i>-Acyltransferase/Acyl-CoA:Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.16 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5284134 | — | — | 1 | 7.21 |
| CHEMBL5274065 | — | — | 1 | 7.16 |
| CHEMBL46423 | NEVANIMIBE | 2.0 | 1 | 6.43 |
| CHEMBL5272794 | — | — | 1 | 5.10 |
| CHEMBL5267472 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5284134 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5274065 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL46423 | NEVANIMIBE | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL5272794 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5267472 | — | IC50 | = | 13000.0 | nM | 4.89 |