Assay Detail
Binding
CHEMBL5243838
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Competitive inhibition of recombinant human lysosomal alpha-glucosidase assessed as inhibition constant by Lineweaver-Burk plot analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Harnessing polyhydroxylated pyrrolidines as a stabilizer of acid alpha-glucosidase (GAA) to enhance the efficacy of enzyme replacement therapy in Pompe disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.52 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406973 | — | — | 1 | 5.85 |
| CHEMBL405957 | — | — | 1 | 5.19 |
| CHEMBL80254 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406973 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL405957 | — | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL80254 | — | Ki | = | 115000.0 | nM | - |