Assay Detail
Binding
CHEMBL5244115
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kgamma (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and in vitro biological evaluation of 2-aminopyridine derivatives as novel PI3Kδ inhibitors for hematological cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.98 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573339 | PI-103 | — | 1 | 7.32 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 7.22 |
| CHEMBL5285343 | — | — | 1 | 6.75 |
| CHEMBL5277394 | — | — | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573339 | PI-103 | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5285343 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5277394 | — | IC50 | = | 243.0 | nM | 6.61 |