Assay Detail
Functional
CHEMBL5244116
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Antiproliferative activity against human MOLM16 cells assessed as inhibition of cell growth
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-16 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and in vitro biological evaluation of 2-aminopyridine derivatives as novel PI3Kδ inhibitors for hematological cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.90 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573339 | PI-103 | — | 1 | 7.24 |
| CHEMBL5277394 | — | — | 1 | 5.58 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573339 | PI-103 | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5277394 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 13300.0 | nM | 4.88 |