Assay Detail
Binding
CHEMBL5244932
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Binding affinity to Trypanosoma cruzi Cruzain assessed as inhibition constant
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship studies of cruzain and rhodesain inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.78 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL564131 | — | — | 1 | 7.80 |
| CHEMBL4761511 | — | — | 1 | 7.60 |
| CHEMBL4752430 | — | — | 1 | 7.20 |
| CHEMBL4784502 | — | — | 1 | 7.20 |
| CHEMBL4776795 | — | — | 1 | 7.20 |
| CHEMBL3233095 | — | — | 1 | 7.10 |
| CHEMBL4799785 | — | — | 1 | 6.70 |
| CHEMBL4463665 | — | — | 1 | 6.60 |
| CHEMBL550246 | — | — | 1 | 6.60 |
| CHEMBL5285296 | — | — | 1 | 6.60 |
| CHEMBL5269694 | — | — | 1 | 6.40 |
| CHEMBL371466 | — | — | 1 | 6.30 |
| CHEMBL2172005 | — | — | 1 | 5.90 |
| CHEMBL1173694 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL564131 | — | Ki | = | 15.8 | nM | 7.80 |
| CHEMBL4761511 | — | Ki | = | 25.1 | nM | 7.60 |
| CHEMBL4752430 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL4784502 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL4776795 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL3233095 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL4799785 | — | Ki | = | 199.0 | nM | 6.70 |
| CHEMBL4463665 | — | Ki | = | 251.0 | nM | 6.60 |
| CHEMBL550246 | — | Ki | = | 251.0 | nM | 6.60 |
| CHEMBL5285296 | — | Ki | = | 251.0 | nM | 6.60 |
| CHEMBL5269694 | — | Ki | = | 398.0 | nM | 6.40 |
| CHEMBL371466 | — | Ki | = | 501.0 | nM | 6.30 |
| CHEMBL2172005 | — | Ki | = | 1260.0 | nM | 5.90 |
| CHEMBL1173694 | — | Ki | = | 2000.0 | nM | 5.70 |