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Assay Detail

CHEMBL5244946

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of alpha-glucosidase (unknown origin) using PNPG as substrate preincubated for 15 mins followed by substrate addition by spectrophotometric assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Maltase-glucoamylase (CHEMBL2074)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A comprehensive review on xanthone derivatives as α-glucosidase inhibitors.
Santos CMM, Freitas M, Fernandes E.
Eur J Med Chem (2018) 157 : 1460 -1479
PubMed 30282319 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.65 5.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL184574 DEMETHYLBELLIDIFOLIN 1 5.28
CHEMBL187043 1 5.14
CHEMBL4856778 1 4.88
CHEMBL5287329 1 4.74
CHEMBL5270478 1 4.70
CHEMBL5271324 1 4.50
CHEMBL404271 ACARBOSE 4.0 1 4.40
CHEMBL5282121 1 4.14
CHEMBL5287286 1 4.06
CHEMBL5287620 1 -
CHEMBL5266980 1 -
CHEMBL5290427 1 -
CHEMBL3704820 1 -
CHEMBL26323 DECUSSATIN 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL184574 DEMETHYLBELLIDIFOLIN IC50 = 5200.0 nM 5.28
CHEMBL187043 IC50 = 7300.0 nM 5.14
CHEMBL4856778 IC50 = 13300.0 nM 4.88
CHEMBL5287329 IC50 = 18300.0 nM 4.74
CHEMBL5270478 IC50 = 20200.0 nM 4.70
CHEMBL5271324 IC50 = 31600.0 nM 4.50
CHEMBL404271 ACARBOSE IC50 = 39800.0 nM 4.40
CHEMBL5282121 IC50 = 71600.0 nM 4.14
CHEMBL5287286 IC50 = 87600.0 nM 4.06
CHEMBL5287620 IC50 = 134500.0 nM -
CHEMBL5266980 IC50 = 395000.0 nM -
CHEMBL5290427 IC50 = 114800.0 nM -
CHEMBL3704820 IC50 = 108200.0 nM -
CHEMBL26323 DECUSSATIN IC50 = 142200.0 nM -