Assay Detail

CHEMBL5245178

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against HCV

ChEMBL ↗

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Target

Hepatitis C virus (CHEMBL379) ↗

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Primary target Hepatitis C virus

CHEMBL379

Anchored from Assay target.

Protein identity Hepatitis C virus

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Hepacivirus hominis
Confidence	1 — Organism
Curated By	Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗

Type	ORGANISM
Organism	Hepacivirus hominis

Publication

Applications of fluorine-containing amino acids for drug design.

Mei H, Han J, Klika KD, Izawa K, Sato T, Meanwell NA, Soloshonok VA.
Eur J Med Chem (2020) 186 : 111826 -111826
PubMed 31740056 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	7.85	8.00

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1779117	—	—	1	8.00
CHEMBL1956820	GS-9256	2.0	1	7.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1779117	—	EC50	=	10.0	nM	8.00
CHEMBL1956820	GS-9256	EC50	=	20.0	nM	7.70