Assay Detail

CHEMBL5245201

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Binding

Inhibition of BCR-Abl (unknown origin)

ChEMBL ↗

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Target

Bcr/Abl fusion protein (CHEMBL2096618) ↗

Open DB target context

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Bcr/Abl fusion protein (CHEMBL2096618) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Bcr/Abl fusion protein

CHEMBL2096618

Anchored from Assay target.

Protein identity Bcr/Abl fusion protein

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	7 — Homologous single protein target
Curated By	Autocuration

Target

Bcr/Abl fusion protein (CHEMBL2096618) ↗

Type	CHIMERIC PROTEIN
Organism	Homo sapiens

Publication

Thiazole-containing compounds as therapeutic targets for cancer therapy.

Sharma PC, Bansal KK, Sharma A, Sharma D, Deep A.
Eur J Med Chem (2020) 188 : 112016 -112016
PubMed 31926469 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	10.80	10.80

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5416410	DASATINIB	4.0	1	10.80

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5416410	DASATINIB	IC50	=	0.016	nM	10.80