Assay Detail
Binding
CHEMBL5245512
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Inhibition of JAK2 (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Janus kinases (JAKs): The efficient therapeutic targets for autoimmune diseases and myeloproliferative disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.94 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21156 | — | — | 1 | 9.00 |
| CHEMBL495727 | AT-9283 | 2.0 | 1 | 8.92 |
| CHEMBL1287853 | FEDRATINIB | 4.0 | 1 | 8.52 |
| CHEMBL4116008 | CERDULATINIB | 2.0 | 1 | 8.22 |
| CHEMBL1995703 | — | — | 1 | 8.22 |
| CHEMBL3622820 | ITACITINIB | 3.0 | 1 | 7.20 |
| CHEMBL3301606 | SOLCITINIB | 2.0 | 1 | 6.97 |
| CHEMBL4564280 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21156 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL495727 | AT-9283 | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1287853 | FEDRATINIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4116008 | CERDULATINIB | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1995703 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3622820 | ITACITINIB | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3301606 | SOLCITINIB | IC50 | = | 107.8 | nM | 6.97 |
| CHEMBL4564280 | — | IC50 | = | 343.0 | nM | 6.46 |