Assay Detail
Binding
CHEMBL5246293
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Inhibition of Trypanosoma cruzi Cruzain
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The role of imidazole and benzimidazole heterocycles in Chagas disease: A review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.12 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3233095 | — | — | 1 | 6.68 |
| CHEMBL3233118 | — | — | 1 | 6.23 |
| CHEMBL3233120 | — | — | 1 | 6.21 |
| CHEMBL1173694 | — | — | 1 | 6.10 |
| CHEMBL1346687 | — | — | 1 | 5.80 |
| CHEMBL1316091 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3233095 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3233118 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3233120 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL1173694 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1346687 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1316091 | — | IC50 | = | 2000.0 | nM | 5.70 |