Assay Detail
Binding
CHEMBL5246777
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of rabbit sGC assessed as induction of preconstricted aortic ring relaxation
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Targeted Drugs for Treatment of Pulmonary Arterial Hypertension: Past, Present, and Future Perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.16 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1916024 | — | — | 1 | 7.00 |
| CHEMBL2107834 | RIOCIGUAT | 4.0 | 1 | 6.92 |
| CHEMBL164996 | — | — | 1 | 6.57 |
| CHEMBL353759 | — | — | 1 | 6.52 |
| CHEMBL348964 | — | — | 1 | 5.77 |
| CHEMBL164712 | — | — | 1 | 5.31 |
| CHEMBL333985 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1916024 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2107834 | RIOCIGUAT | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL164996 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL353759 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL348964 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL164712 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL333985 | — | IC50 | = | 10000.0 | nM | 5.00 |