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Assay Detail

CHEMBL5246784

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Functional
Antimalarial activity against Plasmodium falciparum D6
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Exploration of artemisinin derivatives and synthetic peroxides in antimalarial drug discovery research.
Patel OPS, Beteck RM, Legoabe LJ.
Eur J Med Chem (2021) 213 : 113193 -113193
PubMed 33508479 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 7.64 8.08

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL278291 WR-148999 1 8.08
CHEMBL5290787 1 8.03
CHEMBL319599 1 7.92
CHEMBL5284691 1 7.86
CHEMBL93458 1 7.82
CHEMBL5279896 1 7.70
CHEMBL93291 1 7.64
CHEMBL92197 1 7.64
CHEMBL96830 1 7.52
CHEMBL22590 1 7.42
CHEMBL269671 ARTEMISININ 3.0 1 7.26
CHEMBL5287541 1 6.81
CHEMBL5281793 1 -
CHEMBL5274533 1 -
CHEMBL5272915 1 -
CHEMBL5276019 1 -
CHEMBL2367467 DEOXOARTEMISININ 1 -
CHEMBL2368117 1 -
CHEMBL5284204 1 -
CHEMBL5192558 1 -
CHEMBL5285195 1 -
CHEMBL5266127 1 -
CHEMBL5277080 1 -
CHEMBL5285204 1 -
CHEMBL5289036 1 -
CHEMBL277015 1 -
CHEMBL5284941 1 -
CHEMBL283998 1 -
CHEMBL441514 1 -
CHEMBL565513 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL278291 WR-148999 IC50 = 8.4 nM 8.08
CHEMBL5290787 IC50 = 9.29 nM 8.03
CHEMBL319599 IC50 = 12.0 nM 7.92
CHEMBL5284691 IC50 = 13.8 nM 7.86
CHEMBL93458 IC50 = 15.0 nM 7.82
CHEMBL5279896 IC50 = 20.08 nM 7.70
CHEMBL93291 IC50 = 23.0 nM 7.64
CHEMBL92197 IC50 = 23.0 nM 7.64
CHEMBL96830 IC50 = 30.0 nM 7.52
CHEMBL22590 IC50 = 38.0 nM 7.42
CHEMBL269671 ARTEMISININ IC50 = 55.0 nM 7.26
CHEMBL5287541 IC50 = 155.0 nM 6.81
CHEMBL5280988 IC50 = 0.00191 ug.mL-1 -
CHEMBL5281793 IC50 = 0.00038 ug.mL-1 -
CHEMBL5274533 IC50 = 0.000405 ug.mL-1 -
CHEMBL5272915 IC50 = 0.00248 ug.mL-1 -
CHEMBL5276019 IC50 = 0.00143 ug.mL-1 -
CHEMBL2367467 DEOXOARTEMISININ IC50 = 0.00058 ug.mL-1 -
CHEMBL2368117 IC50 = 0.00041 ug.mL-1 -
CHEMBL5284204 IC50 < 0.00016 ug.mL-1 -
CHEMBL5192558 IC50 = 0.00064 ug.mL-1 -
CHEMBL5285195 IC50 = 0.00066 ug.mL-1 -
CHEMBL5266127 IC50 = 0.00023 ug.mL-1 -
CHEMBL5277080 IC50 = 0.00033 ug.mL-1 -
CHEMBL5285204 IC50 = 0.0009 ug.mL-1 -
CHEMBL5289036 IC50 = 0.0019 ug.mL-1 -
CHEMBL277015 IC50 = 0.00407 ug.mL-1 -
CHEMBL5284941 IC50 = 0.00082 ug.mL-1 -
CHEMBL283998 IC50 > 1000.0 nM -
CHEMBL441514 IC50 > 1000.0 nM -
CHEMBL565513 IC50 = 0.00078 ug.mL-1 -