Assay Detail
Functional
CHEMBL5246785
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against Plasmodium falciparum W2
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration of artemisinin derivatives and synthetic peroxides in antimalarial drug discovery research.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 7.85 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5270759 | — | — | 1 | 9.24 |
| CHEMBL5266617 | — | — | 1 | 9.15 |
| CHEMBL5266403 | — | — | 1 | 9.13 |
| CHEMBL1673094 | — | — | 1 | 9.05 |
| CHEMBL5273991 | — | — | 1 | 8.74 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.70 |
| CHEMBL5283170 | — | — | 1 | 8.69 |
| CHEMBL5286129 | — | — | 1 | 8.62 |
| CHEMBL5290713 | — | — | 1 | 8.37 |
| CHEMBL4645576 | — | — | 1 | 8.21 |
| CHEMBL566534 | ARTEMETHER | 4.0 | 1 | 8.15 |
| CHEMBL278291 | WR-148999 | — | 1 | 8.14 |
| CHEMBL319599 | — | — | 1 | 8.00 |
| CHEMBL5284691 | — | — | 1 | 8.00 |
| CHEMBL96830 | — | — | 1 | 7.82 |
| CHEMBL93458 | — | — | 1 | 7.72 |
| CHEMBL92197 | — | — | 1 | 7.72 |
| CHEMBL93291 | — | — | 1 | 7.68 |
| CHEMBL5288216 | — | — | 1 | 7.62 |
| CHEMBL22590 | — | — | 1 | 7.58 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.50 |
| CHEMBL5288233 | — | — | 1 | 7.16 |
| CHEMBL5281796 | — | — | 1 | 6.80 |
| CHEMBL5283467 | — | — | 1 | 6.60 |
| CHEMBL5270887 | — | — | 1 | 6.57 |
| CHEMBL5276048 | — | — | 1 | 6.37 |
| CHEMBL5268417 | — | — | 1 | 6.36 |
| CHEMBL5271778 | — | — | 1 | 6.20 |
| CHEMBL5284941 | — | — | 1 | - |
| CHEMBL283998 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5270759 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL5266617 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL5266403 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL1673094 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL5273991 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5283170 | — | IC50 | = | 2.04 | nM | 8.69 |
| CHEMBL5286129 | — | IC50 | = | 2.39 | nM | 8.62 |
| CHEMBL5290713 | — | IC50 | = | 4.26 | nM | 8.37 |
| CHEMBL4645576 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL566534 | ARTEMETHER | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL278291 | WR-148999 | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL5284691 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL319599 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL96830 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL93458 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL92197 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL93291 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5288216 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL22590 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5288233 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5281796 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5283467 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5270887 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5276048 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5268417 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5271778 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5281793 | — | IC50 | = | 0.000357 | ug.mL-1 | - |
| CHEMBL5274533 | — | IC50 | = | 0.000313 | ug.mL-1 | - |
| CHEMBL277015 | — | IC50 | = | 0.00138 | ug.mL-1 | - |
| CHEMBL5272915 | — | IC50 | = | 0.00019 | ug.mL-1 | - |
| CHEMBL5276019 | — | IC50 | = | 0.00031 | ug.mL-1 | - |
| CHEMBL2367467 | DEOXOARTEMISININ | IC50 | = | 0.00015 | ug.mL-1 | - |
| CHEMBL2368117 | — | IC50 | = | 0.00016 | ug.mL-1 | - |
| CHEMBL5284204 | — | IC50 | < | 0.00016 | ug.mL-1 | - |
| CHEMBL5192558 | — | IC50 | = | 0.00064 | ug.mL-1 | - |
| CHEMBL5285195 | — | IC50 | = | 0.00066 | ug.mL-1 | - |
| CHEMBL5266127 | — | IC50 | = | 0.00023 | ug.mL-1 | - |
| CHEMBL5277080 | — | IC50 | = | 0.00033 | ug.mL-1 | - |
| CHEMBL5285204 | — | IC50 | = | 0.00135 | ug.mL-1 | - |
| CHEMBL5289036 | — | IC50 | = | 0.0026 | ug.mL-1 | - |
| CHEMBL565513 | — | IC50 | = | 0.00711 | ug.mL-1 | - |
| CHEMBL5280988 | — | IC50 | = | 0.00048 | ug.mL-1 | - |
| CHEMBL441514 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL283998 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5284941 | — | IC50 | = | 0.0065 | ug.mL-1 | - |